John Crutchley

I attended the College of William and Mary. While I was there, I worked in Liz Allison's lab, studying how the thyroid hormone receptor alpha enters the nucleus. After graduating in 2002, I spent two years working at the NCI in the lab of Stuart Yuspa.

I came to Duke through the CMB program and later became a part of UPGG after I joined Danny Lew's lab, which uses yeast genetics to study polarity establishment and cell cycle regulation in budding yeast, S. cerevisiae. Budding yeast are able to sense the presence of a bud and, if there is no bud, they are able to prevent entry into mitosis. I am studying the bud sensor, a kinase known as Hsl1, and trying to determine how it "knows" that the cell has formed a bud.

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