Pharmacology & Cancer Biology
In KrisÕ lab we work primarily on designing better therapeutic strategies for treating different forms of cancer. Two major obstacles in treating nearly all forms of cancer are (1) a given patientÕs tumor may be insensitive to frontline/emerging therapies and (2) patients who initially respond to a drug usually become resistant over the course of treatment; in both cases, the cancer has found some route to avoid the toxic effects of the drug and it continues to grow. My work in KrisÕ lab seeks to address these two problems by understanding the different escape routes cancers use and then design appropriate treatment strategies to account for them. By doing this, we hope to increase the number of people who initially respond to treatment while also slowing the emergence of drug resistance.
Exploring Durham with my wife Melissa and dog Penny!