My work focuses on the role of single-cell genomic and transcriptional variation in B cell malignancies. Leveraging new single-cell techniques in genomic DNA amplification coupled with exome sequencing, I am interrogating the mutational profile of the malignant ReedÐSternberg cells of Hodgkin's Lymphoma. I am also investigating the role of transcriptional variation in the transition of germinal center B cells into plasma cells, as this process has been shown to be implicated in many forms of B cell lymphomas.