UPGG Alumn Seminar Kathy Hentges, PhD, May 19th at 12p

On May 19th at noon (Room 408 CARL), Kathy Hentges (University of Manchester, UK) will give a seminar entitled, "A Tale of Two Mutants: Identifying genes required for left-right axis formation and coronary vessel development”.   

Kathy is a 2004 UPG (before the second G was added!) alumna!    She received her PhD with Andy Peterson working on the second floor of the CARL Building, and then completed postdoctoral research with Monica Justice at Baylor College of Medicine.   After marrying a British citizen, she moved to England to take a faculty position at the University of Manchester.   

Kathy is in town for the Weinstein Conference in Durham, and has expressed interest in meeting with current UPGG and MGM (and any other) students to discuss careers in science.   She is a strong advocate for women in science and is a very lively and engaging person.  We will open the room at 11 AM for anyone wanting to chat with her before her seminar.    We will have pizza and soda available at 11 and then during the seminar as well.   Please consider coming to meet Kathy and then hear her seminar.

Research Description.  http://www.manchester.ac.uk/research/kathryn.hentges/.    Congenital heart defects are one of the most common structural birth defects, present in nearly 1% of live births.  Errors in cardiac development underlie these defects, which range from small, asymptomatic alterations in cardiac structure to severe life-threatening complex malformations requiring urgent surgical correction.  To better understand the causes of congenital heart defects, my laboratory has employed random chemical mutagenesis in the mouse to isolate models of congenital heart defects.   The identification of the causative mutations in one mutant mouse line revealed a role for the major spliceosome protein, Prpf8, in cilia function and cardiac left-right asymmetry.  Additionally, we have found that Non-Muscle Myosin IIB is required for the formation of the coronary vasculature. Therefore, utilising a non-biased mutagenesis approach has extended our knowledge of the genetic requirements for cardiac development.

Join for an informal lunch and chat at 11a in 408 CARL